The Neem Compound May Shrink Prostate Tumors

The Neem Compound May Shrink Prostate Tumors

A compound derived from the leaves of the neem plant could significantly suppress the development of prostate cancer, according to new research with mice.

Prostate cancer is one of the most commonly diagnosed cancers in the world, but current therapies are only marginally effective.

The study found that oral administration of nimbolide could suppress cell invasion and migration of prostate cancer cells without any significant adverse effects. Over a period of 12 weeks, tumor size was reduced by up to 70 percent and its metastasis, or spread, by up to 50 percent.

The nimbolide works by targeting glutathione reductase, an enzyme responsible for maintaining the antioxidant system that regulates the STAT3 gene in the body. This then inhibits STAT3 activation, which has been reported to contribute to prostate tumor growth and metastasis.

“In this research, we have demonstrated that nimbolide can inhibit tumor cell viability—a cellular process that directly affects the ability of a cell to proliferate, grow, divide, or repair damaged cell components—and induce programmed cell death in prostate cancer cells,” says study leader Gautam Sethi, an associate professor in the pharmacology department at NUS Medicine.

Although the anticancer effects of nimbolide have been observed in breast, colon, and oral cancer studies, this is the first time its potential effects on prostate cancer initiation and progression have been shown.

Originally native to India and the Indian sub-continent, the neem plant—part of the mahogany tree family—is commonly found in Singapore. It has been used in traditional Asian medicine for centuries and can also be found in soaps, toothpaste, skincare products, and dietary supplements.

The team plans to conduct further studies into the side effects of nimbolide, other potential molecular targets, as well as the efficacy of nimbolide when combined with other drugs for prostate cancer therapy.

Additional coauthors contributed from the Cancer Science Institute of Singapore at the National University of Singapore, the National Cancer Centre Singapore, and Kyung Hee University in Korea. The findings were published in Antioxidants & Redox Signaling.

Source: National University of Singapore

Related Books:

at InnerSelf Market and Amazon

 

More Articles By This Author

You May Also Like

follow InnerSelf on

facebook icontwitter iconyoutube iconinstagram iconpintrest iconrss icon

 Get The Latest By Email

Weekly Magazine Daily Inspiration

AVAILABLE LANGUAGES

enafarzh-CNzh-TWdanltlfifrdeeliwhihuiditjakomsnofaplptroruesswsvthtrukurvi

INNERSELF VOICES

Lunar eclipse, May 12, 2022
Astrological Overview and Horoscope: May 23 - 29, 2022
by Pam Younghans
This weekly astrological journal is based on planetary influences, and offers perspectives and…
05 21 rewilding the imagination in dangerous times 5362430 1920
Rewilding the Imagination in Dangerous Times
by Natureza Gabriel Kram
In a world that often seems intent on destroying itself, I find myself curating beauty -- the kind…
group of multi-racial individuals standing for a group photo
Seven Ways You Can Show Respect to Your Diverse Team (Video)
by Kelly McDonald
Respect is profoundly meaningful, but costs nothing to give. Here are ways you can demonstrate (and…
elephant walking in front of a setting sun
Astrological Overview and Horoscope: May 16 - 22, 2022
by Pam Younghans
This weekly astrological journal is based on planetary influences, and offers perspectives and…
photo of Leo Buscaglia from cover of his book: Living, Loving and Learning
How to Change Someone's Life in a Few Seconds
by Joyce Vissell
My life was changed dramatically when someone took that second to point out my beauty.
a composite photograph of a total lunar eclipse
Astrological Overview and Horoscope: May 9 - 15, 2022
by Pam Younghans
This weekly astrological journal is based on planetary influences, and offers perspectives and…
05 08 developing compassionate thinking 2593344 completed
Developing Compassionate Thinking Towards Self and Others
by Marie T. Russell, InnerSelf.com
When people speak of compassion, they mostly are referring to having compassion for others... for…
a man writing a letter
Writing the Truth and Allowing the Emotions to Flow
by Barbara Berger
Writing things down is a good way to practice truth telling.
A Day in the Life with Your Spirit Guides
A Day in the Life with Your Spirit Guides
by Debra Landwehr Engle
Approach these conversations exactly the way you would if there were another being sitting next to…
What Is Imposter Syndrome? Do You Have It?
What Is Imposter Syndrome? Do You Have It?
by Dr. Sandi Mann
Welcome to the world of the Imposter Syndrome. It is a secret world, inhabited by successful people…
Does Everyone Have An Inner Compass?
Does Everyone Have An Inner Compass?
by Barbara Berger
How do I know that everyone has an inner compass? To answer this question, let's start by taking a…

MOST READ

finding what you are looking for 5 25
Use Horary Astrology to Find What You Lost
by Alphee Lavoie
There has always been a lot of controversy among astrologers as to what time (and even location) to…
rebuilding environment 4 14
How Native Birds Are Returning To New Zealand’s Restored Urban Forests
by Elizabeth Elliot Noe, Lincoln University et al
Urbanisation, and the destruction of habitat it entails, is a major threat to native bird…
The Story Of Suffering And Death Behind Ireland’s Abortion Ban And Subsequent Legalization
The Story Of Suffering And Death Behind Ireland’s Abortion Ban And Subsequent Legalization
by Gretchen E. Ely, University of Tennessee
If the U.S. Supreme Court overturns Roe v. Wade, the 1973 decision that legalized abortion in the…
how much sleep you need 4 7
How Much Sleep You Really Need
by Barbara Jacquelyn Sahakian, University of Cambridge, et al
Most of us struggle to think well after a poor night’s sleep – feeling foggy and failing to perform…
benefits of lemmon water 4 14
Will Lemon Water Detox Or Energize You?
by Evangeline Mantzioris, University of South Australia
If you believe anecdotes online, drinking lukewarm water with a splash of lemon juice is…
trusting societies are happy 4 14
Why Trusting Societies Are Overall Happier
by enjamin Radcliff, University of Notre Dame
Human beings are social animals. This means, almost as a matter of logical necessity, that humans’…
group of multi-racial individuals standing for a group photo
Seven Ways You Can Show Respect to Your Diverse Team (Video)
by Kelly McDonald
Respect is profoundly meaningful, but costs nothing to give. Here are ways you can demonstrate (and…
economy 4 14
5 Things That Economists Know, But Sound Wrong To Most Other People
by Renaud Foucart, Lancaster University
A curious thing about our profession is that when we academic economists largely agree with each…

New Attitudes - New Possibilities

InnerSelf.comClimateImpactNews.com | InnerPower.net
MightyNatural.com | WholisticPolitics.com | InnerSelf Market
Copyright ©1985 - 2021 InnerSelf Publications. All Rights Reserved.