Why Brains Of Supernormal Seniors Seem To Resist Damage

Why Brains Of Supernormal Seniors Seem To Resist Damage

Scientists are studying a small group of older adults with excellent memories called “supernormals” to determine their risk for Alzheimer’s.

They compared them to older adults at high risk for developing Alzheimer’s disease, and a healthy control group. They specifically measured functional connectivity—the connection among spatially separated structures of the brain—between the cingulate cortex and other regions.

Functional connectivity is measured by observing what parts of the brain are activated at the same time or in rapid succession in response to a stimulus.

“The cingulate cortex acts as a ‘hub’ and receives input from many areas in the brain. Its functioning often deteriorates early in the aging process and in the development of Alzheimer’s disease, so it could play a key role in memory decline,” says Feng (Vankee) Lin, an assistant professor in the University of Rochester School of Nursing. “It’s a vulnerable area that hasn’t been explored in this way before.”

As part of the study, the team analyzed a national data set from the Alzheimer’s Disease Neuroimaging Initiative, which collects brain imaging scans and provides them to researchers across the country. The participants also underwent memory, executive function, language, and other tests to assess their cognitive abilities.

Lin found that individuals who had stronger or more efficient functional connectivity between the cingulate cortex and certain regions of the brain had better memories compared to those who had weaker or less efficient relationships between the same areas.

Supernormals also had lower levels of amyloids, groups of proteins that are associated with Alzheimer’s disease.

But even when amyloids were present, the relationship between better functional connectivity and better memory still remained. These findings indicate that the way the cingulate cortex functions in supernormals may represent exceptional neural reserve—the ability of the mind to resist damage.

This neural reserve could protect supernormals against the effects of amyloid plaques and allow their memories to be maintained.

“Our results show that the cingulate cortex could be a viable target for interventions aimed at preventing memory decline or enhancing memory capacity,” says Lin. “In the future, we may be able to modify the function of this region in individuals who are at risk for developing Alzheimer’s to slow down cognitive decline.”


 Get The Latest By Email

Weekly Magazine Daily Inspiration

Lin hopes to study this topic further with a larger sample size and connect her findings to other studies on the relationship between lipids in the blood and the development of Alzheimer’s disease.

The Alzheimer’s Association and National Institutes of Health supported the study. The team reports their findings in the journal Cortex.

Source: University of Rochester

Related Books:

at InnerSelf Market and Amazon

 

You May Also Like

follow InnerSelf on

facebook icontwitter iconyoutube iconinstagram iconpintrest iconrss icon

 Get The Latest By Email

Weekly Magazine Daily Inspiration

AVAILABLE LANGUAGES

enafarzh-CNzh-TWdanltlfifrdeeliwhihuiditjakomsnofaplptroruesswsvthtrukurvi

MOST READ

digital money 9 15
How Digital Money Has Changed How We Live
by Daromir Rudnyckyj
In simple terms, digital money can be defined as a form of currency that uses computer networks to…
An Equinox Altar
Making An Equinox Altar and Other Fall Equinox Projects
by Ellen Evert Hopman
Fall Equinox is the time when the seas become rough as the winter gales set in. It is also the…
curous kids 9 17
5 Ways To Keep Kids Curious
by Perry Zurn
Kids are naturally curious. But various forces in the environment can dampen their curiosity over…
koala bear "stuck" in a tree
When It’s Smart To Be Slow: Lessons from a Koala Bear
by Danielle Clode
The koala was clinging to an old tree stag while stranded in the Murray River, on the border…
quiet quitting 9 16
Why You Should Talk To Your Boss Before 'Quiet Quitting'
by Cary Cooper
Quiet quitting is a catchy name, popularised on social media, for something we’ve all probably…
woman's face looking at herself
How Could I Have Missed This?
by Mona Sobhani
I began this journey not expecting to find sci­entific evidence for my experiences, because the…
Sedna and Our Emerging World
Sedna and Our Emerging World
by Sarah Varcas
Sedna is the Inuit sea goddess, also known as mother or mistress of the sea and goddess of the…
Like Genes, Your Gut Microbes Pass From One Generation To The Next
Like Genes, Your Gut Microbes Pass from One Generation to the Next
by Taichi A. Suzuki and Ruth Ley
When the first humans moved out of Africa, they carried their gut microbes with them. Turns out,…

New Attitudes - New Possibilities

InnerSelf.comClimateImpactNews.com | InnerPower.net
MightyNatural.com | WholisticPolitics.com | InnerSelf Market
Copyright ©1985 - 2021 InnerSelf Publications. All Rights Reserved.