Researchers have developed a way to reliably predict which chronic pain patients will respond to a sugar placebo pill based on brain anatomy and psychological characteristics.
Doctors may one day prescribe placebos that work as effectively as any painkiller for certain patients, the researchers’ new study suggests.
“Their brain is already tuned to respond,” says senior study author A. Vania Apkarian, professor of physiology at Northwestern University’s Feinberg School of Medicine.
“They have the appropriate psychology and biology that puts them in a cognitive state that as soon as you say, ‘this may make your pain better,’ their pain gets better.”
There’s no need to fool the patient, either, Apkarian says.
“You can tell them, ‘I’m giving you a drug that has no physiological effect but your brain will respond to it,'” he says. “You don’t need to hide it. There is a biology behind the placebo response.”
The findings, which appear in Nature Communications, have three potential benefits:
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- Prescribing non-active drugs rather than active drugs. “It’s much better to give someone a non-active drug rather than an active drug and get the same result,” Apkarian says. “Most pharmacological treatments have long-term adverse effects or addictive properties. Placebo becomes as good an option for treatment as any drug we have on the market.”
- Eliminating the placebo effect from drug trials. “Drug trials would need to recruit fewer people, and identifying the physiological effects would be much easier,” Apkarian says. “You’ve taken away a big component of noise in the study.”
- Reduced health care costs. A sugar pill prescription for chronic pain patients would result in vast cost savings for patients and the health care system, Apkarian says.
A ‘whole new field’
Researchers randomized about 60 chronic back pain patients into two arms of the study. In one arm, people didn’t know if they got the drug or the placebo. Researchers didn’t study the people who got the real drug. The other study arm included people who came to the clinic but didn’t get a placebo or drug. They were the control group.
People who reported a decrease in pain as a result of the sugar pill had a similar brain anatomy and psychological traits. The right side of their emotional brain was larger than the left, and they had a larger cortical sensory area than people who were not responsive to the placebo.
The chronic pain placebo responders also were emotionally self-aware, sensitive to painful situations, and mindful of their environment.
“Clinicians who are treating chronic pain patients should seriously consider that some will get as good a response to a sugar pill as any other drug,” Apkarian says. “They should use it and see the outcome. This opens up a whole new field.”
The National Center for Complementary and Integrative Health, the National Institutes of Health, and the Canadian Institutes of Health Research and Fonds de Recherche Santé Québec funded the work.
Source: Northwestern University