A Mom’s Exposure To Toxic Chemicals Shows Up In Their Newborn

A Mom’s Exposure To Toxic Chemicals Shows Up In Their Newborn

Low-income and Latina pregnant women in a recent study had widespread exposure to environmental pollutants. In addition, many of the toxins showed up at even higher levels in their newborns.

The study is the first in the United States to measure exposure to 59 toxic chemicals in pregnant women and their newborns.

“Pregnant women in the US are exposed to many harmful industrial chemicals that have been linked to premature birth, low birth weight, and birth defects, but estimates of how efficiently pollutants are transferred from mother to fetus have varied widely,” says Tracey Woodruff, professor of obstetrics, gynecology, and reproductive sciences and the Philip R. Lee Institute for Health Policy Studies at the University of California, San Francisco.

“Our findings have found that many chemicals do indeed accumulate in the fetal environment and are absorbed at greater levels by fetuses than by the pregnant women themselves. This may have significant consequences for the growing fetus, since many of these chemicals are known to affect development.”

Researchers measured polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), perfluorinated compounds (PFCs), mercury, and lead, among other chemicals. These industrial pollutants are common in the environment, and in previous studies many have been detected in greater than 99 percent of US pregnant women, according to National Health and Nutrition Examination Survey (NHANES) data.

In the umbilical cord

“Contrary to previous research, we found evidence that several PCBs and OCPs were often higher in umbilical cord samples than in maternal blood samples,” says Rachel Morello-Frosch,  professor of environmental science, policy and management at the University of California, Berkeley.

The study also found that concentrations of mercury and certain PBDEs were often higher in umbilical cord samples than in maternal samples, and for most PFCs and lead, cord blood concentrations were generally equal to or lower than maternal concentrations, which is consistent with previous research.


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Almost 80 percent of the chemicals detected in maternal blood samples were also detected in the umbilical cord blood samples, indicating that they passed through the placenta and entered the fetal environment, where they can pose a health risk to the developing baby.

For those chemicals detected in at least 20 paired maternal and umbilical cord samples, 77 percent had significant correlations between maternal and umbilical cord concentrations.

Understudied groups

The women in the study were participating in the Chemicals in Our Bodies Study, also referred to as the Maternal and Infant Environmental Exposure Project. Of the women participating in the current study, 95 percent had a combined annual household income of less than $40,000, two-thirds were Latina, and a third were born in Mexico, where they may have had less exposure to environmental toxics like the PBDEs found in flame retardants that have been widely used in the US.

This demographic is often not well-represented in larger biomonitoring studies, such as NHANES, that form the basis of most of what is known about pregnant women’s exposure to environmental toxics nationally.

“It is important for researchers to more fully understand chemical exposure trends among women of color, as well as immigrant and low-income women, as thes

The study also provides a first indication of how several different classes of environmental chemicals found in a pregnant woman’s blood are also present in the newborn. And it does so with a broader array of environmental chemicals than has been measured before in a single study.

From 2010 to 2011, researchers collected maternal blood samples from 77 pregnant women at Zuckerberg San Francisco General. Once they delivered their babies, researchers collected umbilical cord blood samples from 65 of these women.

Of those samples tested for all 59 chemicals, the median number was 25 in maternal blood and 17 in umbilical cord blood. Eight of the 59 chemicals analyzed were detected in more than 90 percent of both the maternal and cord blood samples.

“Our findings highlight the need to inform policymakers and the public about the potential health risks of prenatal chemical exposures and reduce the sources of exposure to these compounds,” Woodruff says.

The study appears in the journal Environmental Science and Technology.

Source: UC Berkeley

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