How Fatty Acids Feed Prostate Cancer Tumors

How Fatty Acids Feed Prostate Cancer TumorsA new study shows a link between prostate cancer and cancer cells’ uptake of fatty acids.

The findings point to a possible therapeutic target for this common cancer, the second most diagnosed cancer in men. Prostate cancer accounts for 15 percent of male cancer diagnoses and 8 percent of all cancer cases.

“There is a strong link between obesity, diet, and poor outcomes in men who develop prostate cancer. In particular, those men who consume more saturated fatty acids seem to have more aggressive cancer,” says Renea Taylor, an assistant professor and deputy director of the cancer program at the Monash University Biomedicine Discovery Institute.

The researchers found that fatty acids are taken up into prostate cancer cells and increase tumor growth. They then blocked the uptake of fatty acid by genetically deleting the key fatty acid transporter and showed that they could slow the cancer’s development.

“We’ve known for many years that dysfunctional fatty acid metabolism is linked to many chronic diseases. Applying this knowledge to cancer, and providing the evidence to develop a therapy to treat a disease that impacts so many men is deeply satisfying,” says Matthew Watt, head of the physiology department at the University of Melbourne.

He says the major clinical challenge in the field was to prevent progression to aggressive disease.

“Our whole concept is about giving more appropriate treatment earlier to stop men getting to the late or advanced stage. Our studies showed that blocking fatty acid transport is one way to do this,” Taylor says.

The research appears in Science Translational Medicine.

 Get The Latest From InnerSelf

Source: University of Melbourne

Related Books

{amazonWS:searchindex=Books;keywords=prostate health;maxresults=3}


follow InnerSelf on


 Get The Latest By Email



Why Donald Trump Could Be History's Biggest Loser
by Robert Jennings,
Updated July 2, 20020 - This whole coronavirus pandemic is costing a fortune, maybe 2 or 3 or 4 fortunes, all of unknown size. Oh yeah, and, hundreds of thousands, maybe a million, of people will die…
Blue-Eyes vs Brown Eyes: How Racism is Taught
by Marie T. Russell, InnerSelf
In this 1992 Oprah Show episode, award-winning anti-racism activist and educator Jane Elliott taught the audience a tough lesson about racism by demonstrating just how easy it is to learn prejudice.
A Change Is Gonna Come...
by Marie T. Russell, InnerSelf
(May 30, 2020) As I watch the news on the events in Philadephia and other cities in the country, my heart aches for what is transpiring. I know that this is part of the greater change that is taking…
A Song Can Uplift the Heart and Soul
by Marie T. Russell, InnerSelf
I have several ways that I use to clear the darkness from my mind when I find it has crept in. One is gardening, or spending time in nature. The other is silence. Another way is reading. And one that…
Mascot for the Pandemic and Theme Song for Social Distancing and Isolation
by Marie T. Russell, InnerSelf
I came across a song recently and as I listened to the lyrics, I thought it would be a perfect song as a "theme song" for these times of social isolation. (Lyrics below the video.)